Concepedia

Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules

Tim Luker, Lilian Alcaraz, Kamaldeep K. Chohan, Niklas Blomberg, Dearg S. Brown, Roger J. Butlin, Thomas Elebring, Andrew M. Griffin, Simon D. Guile, Stephen A. St-Gallay,

Bioorganic & Medicinal Chemistry Letters · 2011 · 58 citations · 16 references

DOI

Concepts

References

16

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

, , +16

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering, Jack Bikker, Christine Humblet · Journal of Medicinal Chemistry · 2009 · 4.4K citations

, , +8

On the Interpretation of χ 2 from Contingency Tables, and the Calculation of P

R. A. Fisher · Journal Of The Royal Statistical Society · 1922 · 2.9K citations

, , +13

Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D. Hughes, Julian Blagg, David A. Price et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 973 citations

, , +14

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

M. Paul Gleeson · Journal of Medicinal Chemistry · 2008 · 961 citations

, , +17