Frank Lovering

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering, Jack Bikker, Christine Humblet · Journal of Medicinal Chemistry · 2009 · 4.4K citations

Pharmacy, Chemistry, Medicinal Chemistry +8

Escape from Flatland 2: complexity and promiscuity

Frank Lovering · MedChemComm · 2012 · 1.4K citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

J. Perry Hall, Amy Brault, Fabien Vincent et al. · PLoS ONE · 2017 · 162 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Fluorine in Drug Design: A Case Study with Fluoroanisoles

Xing Li, David C. Blakemore, Arjun Narayanan et al. · ChemMedChem · 2015 · 150 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 145 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17