Novel conversion of epoxides to one carbon homologated allylic alcohols by dimethylsulfonium methylide

Lilian Alcaraz, J. J. HARNETT, Charles Mioskowski, +4

Tetrahedron Letters

EngineeringAlkene MetathesisAllylic AlcoholsOrganic ChemistryDimethylsulfonium Methylide +7

Total Synthesis of the Thiopeptide Antibiotic Amythiamicin D

Rachael A. Hughes, Stewart P. Thompson, Lilian Alcaraz, +1

Journal of the American Chemical Society

Molybdenum-Mediated Carbonylation of Aryl Halides with Nucleophiles Using Microwave Irradiation

Bryan Roberts, David J. Liptrot, Lilian Alcaraz, +2

Organic Letters

Chemical EngineeringEngineeringWide ScopePractical Molybdenum-mediated CarbonylationOrganic Chemistry +8

Conformational Sampling of Macrocyclic Drugs in Different Environments: Can We Find the Relevant Conformations?

Vasanthanathan Poongavanam, Emma Danelius, Stefan Peintner, +7

ACS Omega

Drug TargetMedicinal ChemistryConformational FlexibilityDifferent EnvironmentsMolecular Recognition +14

Manumycin A:  Synthesis of the (+)-Enantiomer and Revision of Stereochemical Assignment

Lilian Alcaraz, Gregor J. Macdonald, Jacques P. Ragot, +2

The Journal of Organic Chemistry

BiosynthesisBioorganic ChemistryBiochemistryNatural SciencesMedicine +13

Biosynthesis inspired Diels–Alder route to pyridines: synthesis of the 2,3-dithiazolylpyridine core of the thiopeptide antibiotics

Christopher J. Moody, Rachael A. Hughes, Stewart P. Thompson, +1

Chemical Communications

Asymmetric synthesis of the mC7N core of the manumycin family: Preparation of (+)-MT 35214 and a formal total synthesis of (−)-alisamycin

Gregor J. Macdonald, Lilian Alcaraz, Norman Lewis, +1

Tetrahedron Letters

BiosynthesisEngineeringBiochemistryMc7n CoreManumycin Family +4

Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X₇Receptor Antagonists/Interleukin-1β Inhibitors

Mark Furber, Lilian Alcaraz, Janice Bent, +23

Journal of Medicinal Chemistry

Rat P2x7 ReceptorImmunologyPharmacotherapyChemical BiologyHuman P2x7 Receptor +14

Novel P2X7 receptor antagonists

Lilian Alcaraz, Andrew Baxter, Jos Bent, +12

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicineMechanism Of ActionReceptor (Biochemistry)Pharmacological Agent +3

Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules

Tim Luker, Lilian Alcaraz, Kamaldeep K. Chohan, +12

Bioorganic & Medicinal Chemistry Letters

Vivo Toxicology OutcomesPreclinical Drug EvaluationPharmacological StudyMedicineImmunology +4