Concepedia

Preclinical Toxicity Testing

Preclinical Toxicity Testing is a systematic biomedical evaluation procedure that assesses the potential adverse effects of pharmacological substances in laboratory animals or in vitro systems prior to human clinical trials, distinguishing it from clinical and post-marketing toxicity assessments by its pre-human experimental stage.

979

Publications

56.3K

Citations

4.2K

Authors

1.1K

Institutions

Publications per year

2017–2026

149

Variants

Preclinical Toxicology

Parents

Children

Publications

979

A new approach to practical acute toxicity testing

Dietrich E. Lorke · Archives of Toxicology · 1983 · 3K citations · Full text

, , +6

Raise standards for preclinical cancer research

C. Glenn Begley, Lee M. Ellis · Nature · 2012 · 2.9K citations · Full text

, , +12

Toxicity Testing in the 21st Century: A Vision and a Strategy

Daniel Krewski, Daniel Acosta, Melvin E. Andersen et al. · Journal of Toxicology and Environmental Health Part B · 2010 · 1.7K citations · Full text

, , +17

Limitations of Animal Studies for Predicting Toxicity in Clinical Trials

Gail A. Van Norman · JACC Basic to Translational Science · 2019 · 663 citations · Full text

, , +15

Transforming Environmental Health Protection

Francis S. Collins, George M. Gray, John R. Bucher · Science · 2008 · 628 citations · Full text

, , +15

1–5 of 979

Authors

4.2K

  1. HS
    Horst Spielmann

    Freie Universität Berlin, Germany

    22 publications · 2.4K citations

    20

    h-index

  2. TH
    Thomas Härtung

    University of Konstanz, Germany

    15 publications · 912 citations

    14

    h-index

  3. MB
    Michael Balls

    University of Nottingham, United Kingdom

    15 publications · 944 citations

    13

    h-index

  4. SB
    Susanne Bremer

    Joint Research Centre, Italy

    11 publications · 1.7K citations

    11

    h-index

  5. AH
    Aldert H. Piersma

    National Institute for Public Health and the Environment, Netherlands

    11 publications · 922 citations

    11

    h-index

1–5 of 4.2K

Institutions

1.1K

  1. Joint Research Centre

    Ispra, Italy

    28 h-index

    104 publications

    7.5K citations

  2. Environmental Protection Agency

    Washington, United States

    24 h-index

    106 publications

    16.2K citations

  3. Research Triangle Park Foundation

    Durham, United States

    24 h-index

    109 publications

    13.8K citations

  4. Pfizer (United States)

    New York, United States

    19 h-index

    78 publications

    4.9K citations

  5. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    17 h-index

    55 publications

    2.8K citations

  6. Bayer (Germany)

    Leverkusen, Germany

    17 h-index

    32 publications

    4.5K citations

  7. National Institute of Environmental Health Sciences

    Durham, United States

    17 h-index

    39 publications

    2.7K citations

  8. United States Food and Drug Administration

    Silver Spring, United States

    16 h-index

    64 publications

    5.1K citations

1–8 of 1.1K

Venues

  1. Alternatives to Laboratory Animals

    56 publications · 3.3K citations

    29

    h-index

  2. Toxicology in Vitro

    46 publications · 2K citations

    27

    h-index

  3. Toxicological Sciences

    31 publications · 3.4K citations

    26

    h-index

  4. PubMed

    Repository · 73 publications · 3K citations

    25

    h-index

  5. Regulatory Toxicology and Pharmacology

    RTP · 32 publications · 1.2K citations

    21

    h-index

1–5