Concepedia

Optimization Of Toxicity

Optimization of Toxicity is a lead compound design strategy that systematically refines molecular structures to minimize adverse biological effects while preserving desired pharmacological activity.

46

Publications

1.8K

Citations

374

Authors

89

Institutions

Publications per year

2017–2026

17

Parents

Publications

46

Synthesis of 4-benzyl-1,3-thiazole derivatives as potential anti-inflammatory agents: An analogue-based drug design approach

Ritesh N. Sharma, Franklin P. Xavier, Kamala K. Vasu et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2009 · 252 citations

, , +13

Designing Drugs to Avoid Toxicity

G. Smith · Progress in medicinal chemistry · 2011 · 116 citations

, , +12

Optimizing Toxic Chemical Removal through Defect‐Induced UiO‐66‐NH<sub>2</sub> Metal–Organic Framework

Gregory W. Peterson, Matthew R. DeStefano, Sergio J. Garibay et al. · Chemistry - A European Journal · 2017 · 88 citations · Full text

, , +16

Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors

Ming‐Qiang Zhang, Sabine Gaisser, Mohammad Nur‐e‐Alam et al. · Journal of Medicinal Chemistry · 2008 · 86 citations · Full text

, , +17

Prioritizing phthalate esters (PAEs) using experimental in vitro/vivo toxicity assays and computational in silico approaches

Naima Hamid, Muhammad Junaid, Rakia Manzoor et al. · Journal of Hazardous Materials · 2020 · 77 citations

, , +16

1–5 of 46

Authors

374

  1. AK
    Astrid Kaiser

    Goethe University Frankfurt, Germany

    2 publications · 46 citations

    2

    h-index

  2. DM
    Daniel Merk

    Goethe University Frankfurt, Germany

    2 publications · 46 citations

    2

    h-index

  3. SS
    Simone Schierle

    Goethe University Frankfurt, Germany

    2 publications · 46 citations

    2

    h-index

  4. QL
    Qing Li

    Fudan University, China

    1 publications · 11 citations

    1

    h-index

  5. BW
    Bo Wang

    Zhengzhou University, China

    1 publications · 14 citations

    1

    h-index

1–5 of 374

Institutions

89

  1. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    3 h-index

    25 publications

    532 citations

  2. Leidos (United States)

    Reston, United States

    2 h-index

    4 publications

    118 citations

  3. Goethe University Frankfurt

    Frankfurt am Main, Germany

    2 h-index

    28 publications

    744 citations

  4. National Cancer Institute

    Bethesda, United States

    1 h-index

    3 publications

    30 citations

  5. Futaba (Japan)

    Mobara, Japan

    1 h-index

    6 publications

    126 citations

  6. RMIT University

    Melbourne, Australia

    1 h-index

    2 publications

    32 citations

  7. University of Tartu

    Tartu, Estonia

    1 h-index

    3 publications

    111 citations

  8. University of Kansas

    Lawrence, United States

    1 h-index

    6 publications

    102 citations

1–8 of 89

Venues

  1. Journal of Medicinal Chemistry

    7 publications · 288 citations

    6

    h-index

  2. European Journal of Medicinal Chemistry

    4 publications · 102 citations

    4

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    3 publications · 107 citations

    3

    h-index

  4. PubMed

    Repository · 3 publications · 75 citations

    3

    h-index

  5. Expert Opinion on Drug Discovery

    2 publications · 95 citations

    2

    h-index

1–5