Concepedia

Author

Simone Schierle

Goethe University Frankfurt

Also Known As

D. Merk, Schierle, Simone, Simone Schierle

20

Publications

346

Citations

12

H-Index

31

Concepts

All Affiliations

Goethe University FrankfurtFraunhofer Institute for Translational Medicine and PharmacologyFraunhofer Institute for Molecular Biology and Applied Ecology
SS

About

Simone Schierle is an author at Goethe University Frankfurt specializing in pharmacology, medicine, and drug discovery.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

6

6

116

2

Natural Sciences

3

3

40

3

Biochemistry

3

3

50

4

Engineering

1

1

26

5

Cell Biology

1

1

13

Simone Schierle

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12

Publications

278

Citations

11

H-Index

YearCitations

Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation

Julius Pollinger, Leonie Gellrich, Simone Schierle,

Journal of Medicinal Chemistry

2019

53

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology

Simone Schierle, Cathrin Flauaus, Pascal Heitel,

Journal of Medicinal Chemistry

2018

37

Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics

Simone Schierle, A. Chaikuad, Felix F. Lillich,

Journal of Medicinal Chemistry

2021

28

Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors

Felix F. Lillich, Sabine Willems, Xiaomin Ni,

Journal of Medicinal Chemistry

2021

28

Design and Structural Optimization of Dual FXR/PPARδ Activators

Simone Schierle, Sebastian Neumann, Pascal Heitel,

Journal of Medicinal Chemistry

2020

26

Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast

Simone Schierle, Moritz Helmstädter, Jurema Schmidt,

ChemMedChem

2019

19

Selective Optimization of Pranlukast to Farnesoid X Receptor Modulators

Simone Schierle, Jurema Schmidt, Astrid Kaiser,

ChemMedChem

2018

18

A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences

Julius Pollinger, Simone Schierle, Leonie Gellrich,

ACS Medicinal Chemistry Letters

2019

16

A triple farnesoid X receptor and peroxisome proliferator-activated receptor α/δ activator reverses hepatic fibrosis in diet-induced NASH in mice

Pascal Heitel, Giuseppe Faudone, Moritz Helmstädter,

Communications Chemistry

2020

16

A New FXR Ligand Chemotype with Agonist/Antagonist Switch

Moritz Helmstädter, Jan Vietor, Jana Sommer,

ACS Medicinal Chemistry Letters

2021

14

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