Nonacidic Farnesoid X Receptor Modulators

Daniel Flesch, Sun-Yee Cheung, Jurema Schmidt, +14

Journal of Medicinal Chemistry

Signal TransductionBiochemistryFunctional SelectivityMedicineLiver Physiology +13

DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators

Pascal Heitel, Janosch Achenbach, Daniel Moser, +2

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineLiver PhysiologyHepatotoxicityPharmacotherapy +3

<scp>l</scp>-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ

Leonie Gellrich, Pascal Heitel, Jan Heering, +16

Journal of Medicinal Chemistry

Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype

Pascal Heitel, Leonie Gellrich, Lena Kalinowsky, +5

ACS Medicinal Chemistry Letters

Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation

Silvia Arifi, Julian A. Marschner, Julius Pollinger, +10

Journal of the American Chemical Society

Lipid PeroxidationMetabolomic ProfilingMolecular BiologyDual BindingInsulin Signaling +17

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology

Simone Schierle, Cathrin Flauaus, Pascal Heitel, +13

Journal of Medicinal Chemistry

InflammationAnti-inflammatoryDesigned PolypharmacologyMedicineImmunology +10

Design and Structural Optimization of Dual FXR/PPARδ Activators

Simone Schierle, Sebastian Neumann, Pascal Heitel, +4

Journal of Medicinal Chemistry

EngineeringMechanical EngineeringChemical ActuatorPharmacotherapyStructural Optimization +22

Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain

Michael Brand, James Clayton, Mustafa Moroglu, +25

Journal of Medicinal Chemistry

Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro

Pascal Heitel, Leonie Gellrich, Jan Heering, +5

Scientific Reports

Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast

Simone Schierle, Moritz Helmstädter, Jurema Schmidt, +9

ChemMedChem