Alfin D. N. Vaz

Epoxidation of olefins by cytochrome P450: Evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant

Alfin D. N. Vaz, Dermot F. McGinnity, Minor J. Coon · Proceedings of the National Academy of Sciences · 1998 · 292 citations

Medicine, Biochemistry, Toxicology +17

The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Tofacitinib, a Janus Kinase Inhibitor, in Humans

Martin E. Dowty, Jinyan Lin, Tim F. Ryder et al. · Drug Metabolism and Disposition · 2014 · 274 citations

Pharmacy, Pharmacokinetics, Pharmacology +12

Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

Martin Newcomb, Runnan Shen, Seung-Yong Choi et al. · Journal of the American Chemical Society · 2000 · 177 citations

Medicine, Biochemistry, Pharmacology +17

Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal.

Elizabeth S. Roberts, Alfin D. N. Vaz, Minor J. Coon · Molecular Pharmacology · 1992 · 164 citations

Life Sciences, Biochemistry, Cellular Metabolism +12

BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4

Amit S. Kalgutkar, Alfin D. N. Vaz, Mary E. Lame et al. · Drug Metabolism and Disposition · 2004 · 154 citations

Medicine, Medicinal Chemistry, Pharmacology +16