Concepedia

Unbound Clearance

Unbound Clearance is the theoretical renal clearance of the pharmacologically active, unbound fraction of a drug from plasma, representing the volume of plasma cleared of free drug per unit time independent of protein binding.

132

Publications

7.6K

Citations

597

Authors

192

Institutions

Publications per year

2017–2026

21

Parents

Publications

132

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 407 citations

, , +17

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, Dermot F. McGinnity, Rupert P. Austin · Drug Metabolism and Disposition · 2005 · 370 citations

, , +17

Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance

M.G. Scordo · Clinical Pharmacology & Therapeutics · 2002 · 344 citations

, , +17

Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches

Natilie Hosea, Wendy T. Collard, Susan Cole et al. · The Journal of Clinical Pharmacology · 2009 · 297 citations

, , +15

Population differences in S‐warfarin metabolism between <i>CYP2C9</i> genotype‐matched Caucasian and Japanese patients

Harumi Takahashi, G. Wilkinson, Yoseph Caraco et al. · Clinical Pharmacology & Therapeutics · 2003 · 189 citations

, , +17

1–5 of 132

Authors

597

  1. HT
    Harumi Takahashi

    Kobe University, Japan

    5 publications · 668 citations

    5

    h-index

  2. SK
    Sosuke Kimura

    Saitama International Medical Center, Japan

    4 publications · 581 citations

    4

    h-index

  3. AG
    Aleksandra Galetin

    University of Manchester, United Kingdom

    4 publications · 455 citations

    4

    h-index

  4. HE
    Hirotoshi Echizen

    Meiji Pharmaceutical University, Japan

    4 publications · 581 citations

    4

    h-index

  5. TK
    Toshitaka Kashima

    Saitama International Medical Center, Japan

    4 publications · 581 citations

    4

    h-index

1–5 of 597

Institutions

192

  1. University of Manchester

    Manchester, United Kingdom

    7 h-index

    14 publications

    1.4K citations

  2. Meiji Pharmaceutical University

    Tokyo, Japan

    6 h-index

    26 publications

    3K citations

  3. The University of Queensland

    Brisbane, Australia

    5 h-index

    17 publications

    415 citations

  4. University of Washington

    Seattle, United States

    4 h-index

    18 publications

    748 citations

  5. Pfizer (United States)

    New York, United States

    4 h-index

    20 publications

    1.7K citations

  6. American Association of Colleges of Pharmacy

    Alexandria, United States

    4 h-index

    12 publications

    474 citations

  7. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    4 h-index

    20 publications

    610 citations

  8. Saitama International Medical Center

    Saitama, Japan

    3 h-index

    19 publications

    3.5K citations

1–8 of 192

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 22 publications · 1.7K citations

    19

    h-index

  2. Drug Metabolism and Disposition

    18 publications · 1.6K citations

    17

    h-index

  3. British Journal of Clinical Pharmacology

    BJCP · 16 publications · 930 citations

    14

    h-index

  4. 8

    h-index

  5. The Journal of Clinical Pharmacology

    7 publications · 457 citations

    7

    h-index

1–5