Sosuke Kimura

Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans

Harumi Takahashi, G. Wilkinson, Edith A. Nutescu et al. · Pharmacogenetics and Genomics · 2006 · 374 citations · Full text

Population differences in S‐warfarin metabolism between <i>CYP2C9</i> genotype‐matched Caucasian and Japanese patients

Harumi Takahashi, G. Wilkinson, Yoseph Caraco et al. · Clinical Pharmacology & Therapeutics · 2003 · 189 citations

Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes*

Harumi Takahashi, Toshitaka Kashima, Yuko Nomizo et al. · Clinical Pharmacology & Therapeutics · 1998 · 184 citations

Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes

Harumi Takahashi, Toshitaka Kashima, Shinichi Nomoto et al. · Pharmacogenetics · 1998 · 163 citations

Determination of unbound warfarin enantiomers in human plasma and 7-hydroxywarfarin in human urine by chiral stationary-phase liquid chromatography with ultraviolet or fluorescence and on-line circular dichroism detection

Harumi Takahashi, Toshitaka Kashima, Sosuke Kimura et al. · Journal of Chromatography B Biomedical Sciences and Applications · 1997 · 75 citations

Human Urine, Medicinal Chemistry, Unbound Warfarin Enantiomers +10