Natilie Hosea

THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL

Angela C. Doran, R. Scott Obach, Bill J. Smith et al. · Drug Metabolism and Disposition · 2004 · 440 citations

Medicine, Pharmacokinetics, Pharmacology +16

Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches

Natilie Hosea, Wendy T. Collard, Susan Cole et al. · The Journal of Clinical Pharmacology · 2009 · 297 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Elucidation of Distinct Ligand Binding Sites for Cytochrome P450 3A4

Natilie Hosea, Grover P. Miller, F. Peter Guengerich · Biochemistry · 2000 · 223 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Evaluation of Selective γ-Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

Ping Wei, Marlena Walls, Ming Qiu et al. · Molecular Cancer Therapeutics · 2010 · 195 citations · Full text

Life Sciences, Oncology, Pharmacology +15

Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding

Xingrong Liu, Bill J. Smith, Cuiping Chen et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 184 citations

Pharmacy, Pharmacokinetics, Pharmacology +15