Bill J. Smith

THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL

Angela C. Doran, R. Scott Obach, Bill J. Smith et al. · Drug Metabolism and Disposition · 2004 · 440 citations

Medicine, Pharmacokinetics, Pharmacology +16

Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches

Natilie Hosea, Wendy T. Collard, Susan Cole et al. · The Journal of Clinical Pharmacology · 2009 · 297 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

DEVELOPMENT OF A COMPUTATIONAL APPROACH TO PREDICT BLOOD-BRAIN BARRIER PERMEABILITY

Xingrong Liu, Meihua Tu, Rebecca S. Kelly et al. · Drug Metabolism and Disposition · 2004 · 241 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human

Mark S. Warren, Noa Zerangue, Katie Woodford et al. · Pharmacological Research · 2009 · 235 citations

Life Sciences, Molecular Biology, Neuroscience +14

Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding

Xingrong Liu, Bill J. Smith, Cuiping Chen et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 184 citations

Pharmacy, Pharmacokinetics, Pharmacology +15