Concepedia

Metabolic Clearance

Metabolic Clearance is the proportion of a drug’s total systemic clearance that is attributable to enzymatic biotransformation processes, distinguished from renal or other non-metabolic elimination mechanisms.

1.4K

Publications

72.8K

Citations

5K

Authors

1K

Institutions

Publications per year

2017–2026

86

Parents

Children

Publications

1.4K

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

Bruce Beutler, Ian W. Milsark, Anthony Cerami · The Journal of Immunology · 1985 · 769 citations

, , +10

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

R. Scott Obach, James G. Baxter, Theodore E. Liston et al. · PubMed · 1997 · 638 citations

, , +14

Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man.

William E. Clutter, Dennis M. Bier, S D Shah et al. · Journal of Clinical Investigation · 1980 · 582 citations · Full text

, , +13

Metabolism and Disposition of Resveratrol in Rats: Extent of Absorption, Glucuronidation, and Enterohepatic Recirculation Evidenced by a Linked-Rat Model

Jean‐Francois Marier, Pascal Vachon, Ari Gritsas et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 478 citations

, , +11

1–5 of 1.4K

Authors

5K

  1. JO
    John O. Miners

    Flinders Medical Centre, Australia

    17 publications · 1.1K citations

    16

    h-index

  2. JB
    J. Brian Houston

    University of Manchester, United Kingdom

    13 publications · 999 citations

    11

    h-index

  3. JB
    J. Brian Houston

    University of Manchester, United Kingdom

    10 publications · 519 citations

    10

    h-index

  4. RS
    R. Scott Obach

    Pfizer (United States), United States

    10 publications · 2K citations

    10

    h-index

  5. AR
    Amin Rostami‐Hodjegan

    University of Manchester, United Kingdom

    8 publications · 577 citations

    8

    h-index

1–5 of 5K

Institutions

1K

  1. Pfizer (United States)

    New York, United States

    23 h-index

    135 publications

    8.8K citations

  2. University of Manchester

    Manchester, United Kingdom

    23 h-index

    67 publications

    5.1K citations

  3. University of California, San Francisco

    San Francisco, United States

    21 h-index

    75 publications

    7.5K citations

  4. University of Washington

    Seattle, United States

    18 h-index

    116 publications

    9.5K citations

  5. National Institutes of Health

    Bethesda, United States

    17 h-index

    63 publications

    3.5K citations

  6. Flinders Medical Centre

    Bedford Park, Australia

    14 h-index

    50 publications

    3.6K citations

  7. University of Toronto

    Toronto, Canada

    14 h-index

    33 publications

    1.5K citations

  8. Vanderbilt University

    Nashville, United States

    13 h-index

    67 publications

    5.7K citations

1–8 of 1K

Venues

  1. Drug Metabolism and Disposition

    123 publications · 9K citations

    46

    h-index

  2. Clinical Pharmacology & Therapeutics

    CPT · 87 publications · 7K citations

    46

    h-index

  3. Journal of Clinical Investigation

    JCI · 46 publications · 5K citations

    40

    h-index

  4. PubMed

    Repository · 94 publications · 4.6K citations

    36

    h-index

  5. The Journal of Clinical Endocrinology & Metabolism

    JCEM · 65 publications · 3.1K citations

    35

    h-index

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