Bruce Beutler

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Alexander Poltorak, Xiaolong He, Irina Smirnova et al. · Science · 1998 · 7.6K citations

Life Sciences, Immunology, Molecular Biology +17

Shock and Tissue Injury Induced by Recombinant Human Cachectin

Kevin J. Tracey, Bruce Beutler, Stephen F. Lowry et al. · Science · 1986 · 2.6K citations

Veterinary Medicine, Immunology, Physiology +17

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

Bruce Beutler, Ian W. Milsark, Anthony Cerami · Science · 1985 · 2.4K citations

Life Sciences, Immunology, Pharmacology +12

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

Daniel Caput, Bruce Beutler, K. Hartog et al. · Proceedings of the National Academy of Sciences · 1986 · 1.5K citations · Full text

Life Sciences, Immunology, Molecular Biology +12

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

C A Dinarello, Joseph G. Cannon, S. M. Wolff et al. · The Journal of Experimental Medicine · 1986 · 1.5K citations · Full text

Life Sciences, Immunology, Pharmacology +12