Concepedia

Hepatocyte Clearance

Hepatocyte Clearance is a pharmacokinetic parameter that quantifies the volume of blood completely cleared of a drug per unit time by hepatic cells, distinguishing it from other clearance mechanisms through its exclusive attribution to intrinsic metabolic and transport activities of hepatocytes.

286

Publications

16.4K

Citations

1.1K

Authors

300

Institutions

Publications per year

2017–2026

67

Parents

Publications

286

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

K. Sandy Pang, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1977 · 798 citations

, , +17

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, Dermot F. McGinnity, Rupert P. Austin · Drug Metabolism and Disposition · 2005 · 370 citations

, , +17

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

Y. Naritomi, Shigeyuki Terashita, Sumihisa Kimura et al. · PubMed · 2001 · 317 citations

, , +17

Studies on a mammalian hepatic binding protein specific for asialoglycoproteins. Evidence for receptor recycling in isolated rat hepatocytes.

Clifford J. Steer, Gilbert Ashwell · Journal of Biological Chemistry · 1980 · 273 citations · Full text

, , +13

EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE

Dermot F. McGinnity, Matthew G. Soars, Richard A. Urbanowicz et al. · Drug Metabolism and Disposition · 2004 · 268 citations

, , +17

1–5 of 286

Authors

1.1K

  1. JB
    J. Brian Houston

    University of Manchester, United Kingdom

    23 publications · 1.7K citations

    21

    h-index

  2. YS
    Yuichi Sugiyama

    The University of Tokyo, Japan

    12 publications · 948 citations

    12

    h-index

  3. LD
    Li Di

    Pfizer (United States), United States

    11 publications · 597 citations

    11

    h-index

  4. DH
    David Hallifax

    University of Manchester, United Kingdom

    11 publications · 562 citations

    11

    h-index

  5. DA
    David A. Tess

    Pfizer (United States), United States

    8 publications · 267 citations

    8

    h-index

1–5 of 1.1K

Institutions

300

  1. University of Manchester

    Manchester, United Kingdom

    27 h-index

    83 publications

    5.1K citations

  2. Pfizer (United States)

    New York, United States

    19 h-index

    147 publications

    8.1K citations

  3. AstraZeneca (Sweden)

    Södertälje, Sweden

    12 h-index

    50 publications

    2.8K citations

  4. The University of Tokyo

    Tokyo, Japan

    11 h-index

    43 publications

    2.4K citations

  5. Roche (Switzerland)

    Basel, Switzerland

    9 h-index

    60 publications

    3.8K citations

  6. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    8 h-index

    23 publications

    1.7K citations

  7. University of California, San Francisco

    San Francisco, United States

    8 h-index

    21 publications

    2.4K citations

  8. University of Washington

    Seattle, United States

    5 h-index

    33 publications

    829 citations

1–8 of 300

Venues

  1. Drug Metabolism and Disposition

    66 publications · 4.9K citations

    40

    h-index

  2. Xenobiotica

    19 publications · 817 citations

    17

    h-index

  3. PubMed

    Repository · 21 publications · 1.1K citations

    16

    h-index

  4. Journal of Pharmaceutical Sciences

    12 publications · 528 citations

    11

    h-index

  5. 10

    h-index

1–5