Concepedia

Hepatic Clearance

Hepatic Clearance is the volume of blood perfusing the liver per unit time from which a drug is completely and irreversibly removed by hepatic mechanisms, including metabolism and biliary excretion.

4.2K

Publications

200.2K

Citations

14.5K

Authors

2.4K

Institutions

Publications per year

2017–2026

313

Parents

Children

Publications

4.2K

A physiological approach to hepatic drug clearance

G. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics · 1975 · 1.9K citations

, , +17

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

The Natural History of Hepatitis C Virus Infection

David L. Thomas, Jacquie Astemborski, Frank A. Anania et al. · JAMA · 2000 · 1.1K citations

, , +17

INDOCYANINE GREEN: OBSERVATIONS ON ITS PHYSICAL PROPERTIES, PLASMA DECAY, AND HEPATIC EXTRACTION*

Gilbert R. Cherrick, Samuel W. Stein, Carroll M. Leevy et al. · Journal of Clinical Investigation · 1960 · 981 citations · Full text

, , +17

Mechanism of hard-nanomaterial clearance by the liver

Kim M. Tsoi, Sonya A. MacParland, Xue‐Zhong Ma et al. · Nature Materials · 2016 · 981 citations · Full text

, , +12

1–5 of 4.2K

Authors

14.5K

  1. YS
    Yuichi Sugiyama

    The University of Tokyo, Japan

    48 publications · 2.7K citations

    30

    h-index

  2. JB
    J. Brian Houston

    University of Manchester, United Kingdom

    32 publications · 2.3K citations

    27

    h-index

  3. MR
    Malcolm Rowland

    University of Manchester, United Kingdom

    29 publications · 2.6K citations

    25

    h-index

  4. KS
    K. Sandy Pang

    University of Toronto, Canada

    44 publications · 2.3K citations

    24

    h-index

  5. KL
    Kim L. R. Brouwer

    University of North Carolina at Chapel Hill, United States

    29 publications · 1.6K citations

    22

    h-index

1–5 of 14.5K

Institutions

2.4K

  1. University of Manchester

    Manchester, United Kingdom

    46 h-index

    184 publications

    10.7K citations

  2. University of California, San Francisco

    San Francisco, United States

    38 h-index

    216 publications

    15.4K citations

  3. The University of Tokyo

    Tokyo, Japan

    36 h-index

    229 publications

    12K citations

  4. Pfizer (United States)

    New York, United States

    34 h-index

    286 publications

    15K citations

  5. Vanderbilt University

    Nashville, United States

    33 h-index

    171 publications

    14.5K citations

  6. Inserm

    Paris, France

    31 h-index

    286 publications

    12.1K citations

  7. Rigshospitalet

    Copenhagen, Denmark

    29 h-index

    137 publications

    6.4K citations

  8. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    29 h-index

    133 publications

    7.3K citations

1–8 of 2.4K

Venues

  1. Drug Metabolism and Disposition

    241 publications · 14K citations

    65

    h-index

  2. PubMed

    Repository · 374 publications · 13.8K citations

    58

    h-index

  3. Clinical Pharmacology & Therapeutics

    CPT · 124 publications · 9.1K citations

    56

    h-index

  4. Journal of Clinical Investigation

    JCI · 78 publications · 9.3K citations

    51

    h-index

  5. Hepatology

    149 publications · 9.7K citations

    48

    h-index

1–5