Discovery of (3<i>S</i>,3a<i>R</i>)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2<i>H</i>-benzo[<i>g</i>]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy

Marvin J. Meyers, Graciela B. Arhancet, Susan L. Hockerman, +17

Journal of Medicinal Chemistry

Excellent PotencyExquisite PotencyRenal InflammationPharmacotherapyExperimental Pharmacology +17

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation

Graciela B. Arhancet, Daniel P. Walker, Sue Metz, +13

Bioorganic & Medicinal Chemistry Letters

InflammationBioavailable Mpges-1 InhibitorAnti-inflammatoryMedicineImmunology +6

Discovery of Novel Cyanodihydropyridines as Potent Mineralocorticoid Receptor Antagonists

Graciela B. Arhancet, Scott S. Woodard, Kaliappan Iyanar, +12

Journal of Medicinal Chemistry

HypertensionFunctional SelectivityMedicinePhysiologyNovel Cyanodihydropyridines +7

Stereochemical Requirements for the Mineralocorticoid Receptor Antagonist Activity of Dihydropyridines

Graciela B. Arhancet, Scott S. Woodard, Jessica D. Dietz, +8

Journal of Medicinal Chemistry

PharmacotherapyChemical BiologyPharmaceutical ChemistryMedicinal ChemistryDhp Diesters +14

Insulin sensitizing pharmacology of thiazolidinediones correlates with mitochondrial gene expression rather than activation of PPAR gamma.

Charles W. Bolten, Patrick M. Blanner, William Graham McDonald, +9

PubMed

Mitochondrial Binding SitePharmacotherapyExperimental PharmacologyInsulin SignalingOxidative Stress +14

Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design

Daniel P. Walker, Graciela B. Arhancet, Hwang‐Fun Lu, +16

Bioorganic & Medicinal Chemistry Letters

Compound DesignConformation-based HypothesisBiochemistryMedicineMechanism Of Action +8

Identification of (<i>R</i>)-6-(1-(4-Cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1<i>H</i>-pyrazol-3-yl)-2-methoxynicotinic Acid, a Highly Potent and Selective Nonsteroidal Mineralocorticoid Receptor Antagonist

Agustin Casimiro‐Garcia, David W. Piotrowski, Catherine M. Ambler, +19

Journal of Medicinal Chemistry

Progesterone Receptor-2-Methoxynicotinic AcidPharmacotherapyExperimental PharmacologyPharmaceutical Chemistry +16

Thermolysis of a Tertiary Alkoxyamine. Recombination and Disproportionation of α-Phenethyl/Diethyl Nitroxyl Radical Pairs

Paul S. Engel, Shaoming Duan, Graciela B. Arhancet

The Journal of Organic Chemistry

Derivative (Chemistry)EngineeringVersus StyreneStyrene ProductTertiary Alkoxyamine +7

Thiazolidinediones inhibit the progression of established hypertension in the Dahl salt-sensitive rat

Charles W. Bolten, Maria Payne, William Graham McDonald, +9

Diabetes and Vascular Disease Research

Insulin Sensitizing Pharmacology of Thiazolidinediones Correlates with Mitochondrial Gene Expression rather than Activation of PPARγ

Charles W. Bolten, Patrick M. Blanner, William Graham McDonald, +9

Gene Regulation and Systems Biology

Mitochondrial Binding SitePharmacotherapyExperimental PharmacologyInsulin SignalingTranslational Pharmacology +19