Jeffrey A. Scholten

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

Mark E. Schnute, Matthew D. McReynolds, Tom Kasten et al. · Biochemical Journal · 2012 · 278 citations

Life Sciences, Cell Biology, Pharmacology +12

Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits

Mark E. Schnute, Matthew D. McReynolds, Jeffrey Carroll et al. · Journal of Medicinal Chemistry · 2017 · 54 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +10

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Mark E. Schnute, Patrick O’Brien, Joe Nahra et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 50 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Discovery of<i>N</i>-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2<i>S</i>,5<i>R</i>)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2<i>H</i>-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis

Peter Ruminski, Mark A. Massa, Joseph W. Strohbach et al. · Journal of Medicinal Chemistry · 2015 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design

Daniel P. Walker, Graciela B. Arhancet, Hwang‐Fun Lu et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 27 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10