Joseph P. Vacca

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

Joseph P. Vacca, Bruce D. Dorsey, William A. Schleif et al. · Proceedings of the National Academy of Sciences · 1994 · 526 citations

Medicine, Pharmacokinetics, Pharmacology +17

L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor

Bruce D. Dorsey, Rhonda B. Levin, Joseph P. Vacca et al. · Journal of Medicinal Chemistry · 1994 · 411 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

Jay A. Grobler, Kara A. Stillmock, Binghua Hu et al. · Proceedings of the National Academy of Sciences · 2002 · 396 citations

Life Sciences, Biology, Molecular Biology +17

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Daria J. Hazuda, Neville J. Anthony, Robert Gomez et al. · Proceedings of the National Academy of Sciences · 2004 · 333 citations · Full text

Life Sciences, Pharmacokinetics, Pharmacology +17

Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

Daria J. Hazuda, Steven D. Young, James P. Guare et al. · Science · 2004 · 284 citations · Full text

Life Sciences, Immunology, Pharmacology +17