Jon F. Denissen

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

Dale J. Kempf, Kennan C. Marsh, Jon F. Denissen et al. · Proceedings of the National Academy of Sciences · 1995 · 551 citations · Full text

Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir

Dale J. Kempf, Kennan C. Marsh, Gondi Kumar et al. · Antimicrobial Agents and Chemotherapy · 1997 · 418 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +15

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

Gondi Kumar, A. David Rodrigues, Alex Buko et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 351 citations

Multiple-dose pharmacokinetics of ritonavir in human immunodeficiency virus-infected subjects

Ann Hsu, G. Richard Granneman, Galen Witt et al. · Antimicrobial Agents and Chemotherapy · 1997 · 186 citations · Full text

Pharmacology, Immunology, Antiviral Therapy +10

Human Serum Attenuates the Activity of Protease Inhibitors toward Wild-Type and Mutant Human Immunodeficiency Virus

Akhteruzzaman Molla, Sudthida Vasavanonda, Gondi Kumar et al. · Virology · 1998 · 177 citations

Protease Inhibitors, Biochemistry, Medicine +13