Steven E. Heasley

Identification of <i>N</i>-{<i>cis</i>-3-[Methyl(7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases

Michael L. Vazquez, Neelu Kaila, Joseph W. Strohbach et al. · Journal of Medicinal Chemistry · 2018 · 171 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation

Graciela B. Arhancet, Daniel P. Walker, Sue Metz et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 48 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

Steven P. Tanis, Bruce R. Evans, James A. Nieman et al. · Tetrahedron Asymmetry · 2006 · 41 citations

Natural Sciences, Chemical Engineering, Chemistry +17

Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility

James A. Nieman, Sajiv K. Nair, Steven E. Heasley et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of 3-Cyano- <i>N</i> -(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 <i>H</i> -pyrrolo[2,3- <i>b</i> ]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist

Mark E. Schnute, Mattias Wennerstål, Jennifer Alley et al. · Journal of Medicinal Chemistry · 2018 · 32 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17