James A. Nieman

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

Robert L. Hoffman, Robert S. Kania, Mary A. Brothers et al. · Journal of Medicinal Chemistry · 2020 · 533 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +15

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

Wade Blair, Chris Pickford, S.L. Irving et al. · PLoS Pathogens · 2010 · 301 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

Vincent Hernandez, Thibaut Crépin, Andrés Palencia et al. · Antimicrobial Agents and Chemotherapy · 2013 · 196 citations · Full text

Life Sciences, Medicinal Chemistry, Microbiology +17

HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Frank Loganzo, Carolyn Discafani, Tami Annable et al. · PubMed · 2003 · 137 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors

Aravindhan Ganesan, Marawan Ahmed, Isobel Okoye et al. · Scientific Reports · 2019 · 134 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17