Sajiv K. Nair

1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long–sought-after mimetics for <i>ortho</i> / <i>meta</i> -substituted arenes

Jin‐Xin Zhao, Yuxuan Chang, Chi He et al. · Proceedings of the National Academy of Sciences · 2021 · 118 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Discovery of <i>N</i>-((3<i>R</i>,4<i>R</i>)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1<i>H</i>-pyrazol-4-yl)amino)-9-methyl-9<i>H</i>-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Simon Planken, Douglas C. Behenna, Sajiv K. Nair et al. · Journal of Medicinal Chemistry · 2017 · 90 citations · Full text

Medicine, Oncology, Pharmacology +12

Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood–Brain Barrier

Allison Rohner, Mary E. Spilker, Justine L. Lam et al. · Molecular Cancer Therapeutics · 2011 · 51 citations

Medicine, Oncology, Pharmacology +17

CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

Cynthia L. Palmer, Britton Boras, Bernadette Pascual et al. · Cancer Cell · 2025 · 51 citations · Full text

Medicine, Oncology, Pharmacology +13

Total Synthesis of Cryptophycin-24 (Arenastatin A) Amenable to Structural Modifications in the C16 Side Chain

MariJean Eggen, Craig J. Mossman, Suzanne B. Buck et al. · The Journal of Organic Chemistry · 2000 · 50 citations

Pharmacy, Chemistry, Medicinal Chemistry +16