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Structure-based optimization of aminopyridines as PKCθ inhibitors

Juan‐Miguel Jimenez, Christopher J. Davis, Dean Boyall, Damien Fraysse, Ronald M. A. Knegtel, Luca Settimo, Stephen Young, Claire M. Bolton, Adam P. Curnock, Richele K. Rasmussen,

Bioorganic & Medicinal Chemistry Letters · 2012 · 10 citations · 15 references

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15

Protein Kinase C θ Is Critical for the Development of In Vivo T Helper (Th)2 Cell But Not Th1 Cell Responses

Benjamin J. Marsland, Timothy Soos, Gérald F. Späth et al. · The Journal of Experimental Medicine · 2004 · 203 citations · Full text

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Discovery of potent and selective PKC-θ inhibitors

Charles L. Cywin, Georg Dahmann, Anthony S. Prokopowicz et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 70 citations · Full text

, , +12

Differential Roles of PKC-θ in the Regulation of Intracellular Calcium Concentration in Primary T Cells

Santhakumar Manicassamy, Maureen Sadim, Richard D. Ye et al. · Journal of Molecular Biology · 2005 · 53 citations

, , +15

Identification, Characterization and Initial Hit-to-Lead Optimization of a Series of 4-Arylamino-3-Pyridinecarbonitrile as Protein Kinase C theta (PKCθ) Inhibitors

Derek C. Cole, Magda Asselin, Agnes Brennan et al. · Journal of Medicinal Chemistry · 2008 · 45 citations · Full text

, , +15

2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCθ

L. Nathan Tumey, Diane H. Boschelli, Julie Lee et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 43 citations · Full text

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