Charles L. Cywin

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

Liang Tong, Susan Pav, Della White et al. · Nature Structural Biology · 1997 · 386 citations

Specific Inhibitor, Signal Transduction, Signaling Pathway +11

Enantioselective Mukaiyama-aldol and aldol-dihydropyrone annulation reactions catalyzed by a tryptophan-derived oxazaborolidine

E. J. Corey, Charles L. Cywin, Thomas D. Roper · Tetrahedron Letters · 1992 · 217 citations

Aldol-dihydropyrone Annulation Reactions, Engineering, Tryptophan-derived Oxazaborolidine +10

Effect of Structural Modification of Enol−Carboxamide-Type Nonsteroidal Antiinflammatory Drugs on COX-2/COX-1 Selectivity

Edward S. Lazer, Clara K. Miao, Charles L. Cywin et al. · Journal of Medicinal Chemistry · 1997 · 92 citations · Full text

Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors

Yancey D. Ward, David Thomson, Leah L. Frye et al. · Journal of Medicinal Chemistry · 2002 · 83 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Target Enzyme +14

Discovery of potent and selective PKC-θ inhibitors

Charles L. Cywin, Georg Dahmann, Anthony S. Prokopowicz et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 69 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Drug Target +7