Adam P. Curnock

Dihydroorotate Dehydrogenase Is a High Affinity Binding Protein for A77 1726 and Mediator of a Range of Biological Effects of the Immunomodulatory Compound

Richard A. Williamson, Christopher Yea, P.A. Robson et al. · Journal of Biological Chemistry · 1995 · 196 citations · Full text

Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors

Adam P. Curnock, Giovanna Bossi, Jyothi Kumaran et al. · JCI Insight · 2021 · 70 citations · Full text

Key Immune Checkpoint, T-regulatory Cell, Immunology +19

Discovery and Structure−Activity Relationship of 3-Aminopyrid-2-ones as Potent and Selective Interleukin-2 Inducible T-Cell Kinase (Itk) Inhibitors

Jean‐Damien Charrier, Andrew T. Miller, David P. Kay et al. · Journal of Medicinal Chemistry · 2011 · 60 citations · Full text

Kinase Active Site, Medicinal Chemistry, Drug Target +14

Optimal Chemotactic Responses of Leukemic T Cells to Stromal Cell-Derived Factor-1 Requires the Activation of Both Class IA and IB Phosphoinositide 3-Kinases

Adam P. Curnock, Yannis Sotsios, Karen L. Wright et al. · The Journal of Immunology · 2003 · 58 citations · Full text

Design and Optimization of Selective Protein Kinase C θ (PKCθ) Inhibitors for the Treatment of Autoimmune Diseases

Juan‐Miguel Jimenez, Dean Boyall, Guy Brenchley et al. · Journal of Medicinal Chemistry · 2013 · 46 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +25