Synthesis of the First Members of a New Class of Biologically Active Bryostatin Analogues

Paul A. Wender, Jef K. De Brabander, Patrick G. Harran, +5

Journal of the American Chemical Society

Synthesis and Biological Evaluation of 3,4-Diaryloxazolones:  A New Class of Orally Active Cyclooxygenase-2 Inhibitors

Carles Puig, M. Crespo, Núria Godessart, +13

Journal of Medicinal Chemistry

Medicinal ChemistryCox-2 SelectivityPharmaceutical ScienceAnti-inflammatoryBiochemistry +13

Discovery and Structure−Activity Relationship of 3-Aminopyrid-2-ones as Potent and Selective Interleukin-2 Inducible T-Cell Kinase (Itk) Inhibitors

Jean‐Damien Charrier, Andrew T. Miller, David P. Kay, +11

Journal of Medicinal Chemistry

Kinase Active SiteMedicinal ChemistryDrug TargetAllergyNovel Therapy +12

Design and Optimization of Selective Protein Kinase C θ (PKCθ) Inhibitors for the Treatment of Autoimmune Diseases

Juan‐Miguel Jimenez, Dean Boyall, Guy Brenchley, +13

Journal of Medicinal Chemistry

T-regulatory CellImmunologyImmune RegulationImmunodominanceSelective Pkcθ Inhibitors +23

Nucleophilic Addition of 1-Acetylindole Enolates to Pyridinium Salts. Stereoselective Formal Synthesis of (±)-Geissoschizine and (±)-Akagerine via 1,4-Dihydropyridines

M.-Lluı̈sa Bennasar, Juan‐Miguel Jimenez, Bernat Vidal, +2

The Journal of Organic Chemistry

Diversity Oriented SynthesisHeterocyclicNatural SciencesDiversity-oriented SynthesisNucleophilic Addition +12

Synthesis and Biological Evaluation of 2-Phenylpyran-4-ones:  A New Class of Orally Active Cyclooxygenase-2 Inhibitors

Francisco Caturla, Juan‐Miguel Jimenez, Núria Godessart, +5

Journal of Medicinal Chemistry

A concise, stereoselective synthesis of (±)-geissoschizine

M.-Lluı̈sa Bennasar, Juan‐Miguel Jimenez, Bilal A. Sufi, +1

Tetrahedron Letters

Organic ChemistrySynthetic ChemistryStereoselective SynthesisChemistry

Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases

Christophe Peixoto, Agnès Joncour, Taouès Temal-Laib, +22

Journal of Medicinal Chemistry

The chemistry-medicine continuum: Synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads

Paul A. Wender, Yolanda Martín-Cantalejo, Andrew J. Carpenter, +15

Pure and Applied Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryNatural SciencesMedicine +10

Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis

Philip N. Collier, Heather Twin, Ronald M. A. Knegtel, +14

ACS Medicinal Chemistry Letters