Diane H. Boschelli

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.

Jennifer M. Golas, Kim Arndt, Carlo Etienne et al. · PubMed · 2003 · 414 citations

K562 Xenografts, Mixed-phenotype Acute Leukemia, Apoptosis +18

Optimization of 4-Phenylamino-3-quinolinecarbonitriles as Potent Inhibitors of Src Kinase Activity

Diane H. Boschelli, Fei Ye, Yanong D. Wang et al. · Journal of Medicinal Chemistry · 2001 · 219 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Bioorganic Chemistry +14

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors

Allan Wissner, Dan M. Berger, Diane H. Boschelli et al. · Journal of Medicinal Chemistry · 2000 · 208 citations · Full text

Pharmaceutical Science, Organic Chemistry, Pharmacotherapy +19

1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities

Diane H. Boschelli, David T. Connor, Dirk A. Bornemeier et al. · Journal of Medicinal Chemistry · 1993 · 202 citations · Full text

Compound 5B, Medicinal Chemistry, Vitro Inhibition +14

SKI-606, a Src/Abl Inhibitor with<i>In vivo</i>Activity in Colon Tumor Xenograft Models

Jennifer M. Golas, Judy Lucas, Carlo Etienne et al. · Cancer Research · 2005 · 133 citations · Full text

Cancer Biology, Tumor Biology, Signaling Pathway +18