4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors

Allan Wissner, Dan M. Berger, Diane H. Boschelli, +14

Journal of Medicinal Chemistry

Pharmaceutical ScienceOrganic ChemistryPharmacotherapyDermatologyHeterocycle Chemistry +17

Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

Lori M. Miller, Scott C. Mayer, Dan M. Berger, +15

Bioorganic & Medicinal Chemistry Letters

MedicinePathologyLead IdentificationFibroblast Growth FactorAnti-cancer Agent +8

Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors

Dan M. Berger, Nancy Torres, Minu Dutia, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineRational Drug DesignPharmacotherapyAnti-cancer Agent +2

Dramatic Effect of Solvent Hydrogen Bond Basicity on the Regiochemistry of S_NAr Reactions of Electron-Deficient Polyfluoroarenes

Xiaolun Wang, Edward J. Salaski, Dan M. Berger, +1

Organic Letters

HalogenationBiochemistryNatural SciencesChemical BondHydrogen Bond +8

Novel pyrazolopyrimidines as highly potent B-Raf inhibitors

Martin J. Di Grandi, Dan M. Berger, Darrin W. Hopper, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineNovel PyrazolopyrimidinesPharmacological AgentPharmacotherapy +5

Discovery of highly potent and selective type I B-Raf kinase inhibitors

Xiaolun Wang, Dan M. Berger, Edward J. Salaski, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetMedicineReceptor Tyrosine KinaseRational Drug Design +7

Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1

Keith R. Hornberger, Dan M. Berger, Andrew P. Crew, +21

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryMedicineRational Drug DesignPharmacology +2

Synthesis and biological evaluation of tricyclic anilinopyrimidines as IKKβ inhibitors

Aimee L. Crombie, Fuk‐Wah Sum, Dennis Powell, +7

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +6

4-Anilino-7,8-dialkoxybenzo[<i>g</i>]quinoline-3-carbonitriles as Potent Src Kinase Inhibitors

Dan M. Berger, Minu Dutia, Gary H. Birnberg, +8

Journal of Medicinal Chemistry

4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors

Dan M. Berger, Minu Dutia, Dennis Powell, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicineAnti-cancer AgentDrug DevelopmentPharmacology +1