Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

Lori M. Miller, Scott C. Mayer, Dan M. Berger, +15

Bioorganic & Medicinal Chemistry Letters

MedicinePathologyLead IdentificationFibroblast Growth FactorAnti-cancer Agent +8

Hydrophobic Acetal and Ketal Derivatives of Mannopeptimycin-α and Desmethylhexahydromannopeptimycin-α:  Semisynthetic Glycopeptides with Potent Activity Against Gram-Positive Bacteria

Russell G. Dushin, Tingzhong Wang, Phaik-Eng Sum, +16

Journal of Medicinal Chemistry

Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors

Dan M. Berger, Nancy Torres, Minu Dutia, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineRational Drug DesignPharmacotherapyAnti-cancer Agent +2

Synthesis and activity of novel benzoxazole derivatives of mannopeptimycin glycopeptide antibiotics

Phaik‐Eng Sum, David How, Nancy Torres, +3

Bioorganic & Medicinal Chemistry Letters

Derivative (Chemistry)DerivativesChemical DerivativeSynthetic ChemistryMannopeptimycin Glycopeptide Antibiotics +4

Novel pyrazolopyrimidines as highly potent B-Raf inhibitors

Martin J. Di Grandi, Dan M. Berger, Darrin W. Hopper, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineNovel PyrazolopyrimidinesPharmacological AgentPharmacotherapy +5

Synthesis and evaluation of 4-Anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade

Dan Berger, Minu Dutia, Dennis Powell, +15

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryMedicineReceptor Tyrosine KinaseRas-mapk Signaling Cascade +4

Discovery of highly potent and selective type I B-Raf kinase inhibitors

Xiaolun Wang, Dan M. Berger, Edward J. Salaski, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetMedicineReceptor Tyrosine KinaseRational Drug Design +7

Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics

Phaik‐Eng Sum, David How, Nancy Torres, +5

Bioorganic & Medicinal Chemistry Letters

Derivative (Chemistry)DerivativesEngineeringOrganic ChemistryStereoselective Synthesis +5

Novel ether derivatives of mannopeptimycin glycopeptide antibiotic

Phaik‐Eng Sum, David How, Nancy Torres, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryNatural SciencesMedicine +5

Synthesis and biological evaluation of tricyclic anilinopyrimidines as IKKβ inhibitors

Aimee L. Crombie, Fuk‐Wah Sum, Dennis Powell, +7

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +6