Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells

Thomas Strömberg · Blood · 2005 · 157 citations

Life Sciences, Oncology, Pharmacology +17

Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells

Jing Fang, Qianjun Zhou, Xiangchao Shi et al. · Carcinogenesis · 2006 · 144 citations · Full text

Medicine, Oncology, Pharmacology +11

Crystal Structure of Bisphosphorylated IGF-1 Receptor Kinase

Alexander Pautsch, Andreas Zoephel, Horst Ahorn et al. · Structure · 2001 · 94 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Structural and Kinetic Studies of a Cisplatin-modified DNA Icosamer Binding to HMG1 Domain B

Elizabeth R. Jamieson, Matthew P. Jacobson, Carmen M. Barnés et al. · Journal of Biological Chemistry · 1999 · 69 citations · Full text

Medicine, Molecular Biology, Oncology +14

Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

Scott C. Mayer, A. Banker, Frank Boschelli et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 68 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17