Frank Boschelli

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.

Jennifer M. Golas, Kim Arndt, Carlo Etienne et al. · PubMed · 2003 · 414 citations

K562 Xenografts, Mixed-phenotype Acute Leukemia, Apoptosis +18

<i>In vitro</i> and <i>In vivo</i> Activity of SKI-606, a Novel Src-Abl Inhibitor, against Imatinib-Resistant Bcr-Abl+ Neoplastic Cells

Miriam Puttini, Addolorata Maria Luce Coluccia, Frank Boschelli et al. · Cancer Research · 2006 · 368 citations

Hematological Malignancy, Cell Signaling, Ski-606 Activity +13

Optimization of 4-Phenylamino-3-quinolinecarbonitriles as Potent Inhibitors of Src Kinase Activity

Diane H. Boschelli, Fei Ye, Yanong D. Wang et al. · Journal of Medicinal Chemistry · 2001 · 219 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Bioorganic Chemistry +14

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells

Adina Vultur, Ralf Buettner, Claudia Kowolik et al. · Molecular Cancer Therapeutics · 2008 · 165 citations · Full text

A Src/Abl Kinase Inhibitor, SKI-606, Blocks Breast Cancer Invasion, Growth, and Metastasis <i>In vitro</i> and <i>In vivo</i>

Houda Jallal, Maria-Luisa Valentino, Gaoping Chen et al. · Cancer Research · 2007 · 147 citations

Breast Cancer Growth, Breast Oncology, Endocrine-related Cancer +14