Concepedia

Structure-based Lead Identification

Structure-Based Lead Identification is a computational drug discovery approach that identifies potential lead compounds by leveraging the three-dimensional structure of a biological target to guide the search for molecules capable of specifically interacting with functionally relevant sites.

196

Publications

10.6K

Citations

1.7K

Authors

424

Institutions

Publications per year

2017–2026

74

Parents

Publications

196

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Wenhao Dai, Bing Zhang, Xia-Ming Jiang et al. · Science · 2020 · 1.6K citations · Full text

, , +17

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

E. Wahlberg, T. Karlberg, E. Kouznetsova et al. · Nature Biotechnology · 2012 · 460 citations

, , +16

Structure-Based Identification of Small-Molecule Angiotensin-Converting Enzyme 2 Activators as Novel Antihypertensive Agents

J.A. Hernandez Prada, Anderson J. Ferreira, Michael J. Katovich et al. · Hypertension · 2008 · 270 citations

, , +17

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Andrew Woodhead, Hayley C. Angove, Maria G. Carr et al. · Journal of Medicinal Chemistry · 2010 · 263 citations

, , +17

New roles for structure in biology and drug discovery.

Robert B. Russell, Drake S. Eggleston · Nature Structural Biology · 2000 · 199 citations

, , +14

1–5 of 196

Authors

1.7K

  1. BC
    Brian Cutting

    University of Basel, Switzerland

    3 publications · 95 citations

    3

    h-index

  2. CW
    Christopher W. Murray

    Proteus (United Kingdom), United Kingdom

    3 publications · 491 citations

    3

    h-index

  3. OS
    Oliver Schwardt

    University of Basel, Switzerland

    3 publications · 95 citations

    3

    h-index

  4. HK
    Hendrik Koliwer‐Brandl

    University of Bremen, Germany

    3 publications · 95 citations

    3

    h-index

  5. BE
    Beat Ernst

    University of Basel, Switzerland

    3 publications · 95 citations

    3

    h-index

1–5 of 1.7K

Institutions

424

  1. Chinese Academy of Sciences

    Beijing, China

    9 h-index

    74 publications

    25.7K citations

  2. Shanghai Institute of Materia Medica

    Pudong, China

    5 h-index

    44 publications

    20.2K citations

  3. University of Chinese Academy of Sciences

    Beijing, China

    5 h-index

    24 publications

    13.6K citations

  4. Xiamen University

    Xiamen, China

    4 h-index

    22 publications

    478 citations

  5. Central China Normal University

    Wuhan, China

    3 h-index

    30 publications

    642 citations

  6. University of Basel

    Basel, Switzerland

    3 h-index

    22 publications

    702 citations

  7. King Saud University

    Riyadh, Saudi Arabia

    3 h-index

    5 publications

    141 citations

  8. Johnson & Johnson (United States)

    New Brunswick, United States

    3 h-index

    22 publications

    798 citations

1–8 of 424

Venues

  1. Journal of Medicinal Chemistry

    39 publications · 2.9K citations

    32

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    17 publications · 517 citations

    15

    h-index

  3. European Journal of Medicinal Chemistry

    13 publications · 465 citations

    13

    h-index

  4. Bioorganic & Medicinal Chemistry

    13 publications · 430 citations

    13

    h-index

  5. Journal of Chemical Information and Modeling

    JCIM · 5 publications · 165 citations

    5

    h-index

1–5