Xiaolun Wang

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS ^G12D Inhibitor

Xiaolun Wang, Shelley Allen, James F. Blake et al. · Journal of Medicinal Chemistry · 2021 · 644 citations · Full text

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

Jill Hallin, Vickie Bowcut, Andrew Calinisan et al. · Nature Medicine · 2022 · 465 citations

Medicine, Pharmacology, Pharmacotherapy +7

Strained Silacycles in Organic Synthesis:  A New Reagent for the Enantioselective Allylation of Aldehydes

James W. A. Kinnaird, Pui Yee Ng, Katsumi Kubota et al. · Journal of the American Chemical Society · 2002 · 177 citations

Enantioselective Synthesis, Engineering, Strain-release Lewis Acidity +10

Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of <i>MTAP</i> -Deleted Cancers

Christopher R. Smith, Ruth Aranda, Thomas P. Bobinski et al. · Journal of Medicinal Chemistry · 2022 · 139 citations · Full text

Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction

John M. Ketcham, Jacob R. Haling, Shilpi Khare et al. · Journal of Medicinal Chemistry · 2022 · 87 citations · Full text