Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects

Adam R. Johnson, A.G. Pavlovsky, Daniel F. Ortwine, +15

Journal of Biological Chemistry

1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities

Diane H. Boschelli, David T. Connor, Dirk A. Bornemeier, +6

Journal of Medicinal Chemistry

Compound 5BMedicinal ChemistryVitro InhibitionBiochemistryMedicine +12

Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-<i>tert</i>-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 1. Thiazolone and Oxazolone Series

Yuntao Song, David T. Connor, Robert Doubleday, +10

Journal of Medicinal Chemistry

Pharmaceutical ScienceChemoprevention StrategyPharmacotherapyPharmaceutical ChemistryDrug Resistance +18

Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-<i>tert</i>-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 2. 1,3,4- and 1,2,4-Thiadiazole Series

Yuntao Song, David T. Connor, Anthony D. Sercel, +11

Journal of Medicinal Chemistry

Chemoprevention StrategyGastrointestinal PharmacologyImmunologyPathologyPharmacotherapy +21

Purification of a mammalian 5-lipoxygenase from rat basophilic leukemia cells

Andrew M. Goetze, Liz Fayer, Jennifer B. Bouska, +2

Prostaglandins

BiochemistryNatural SciencesLipid PeroxidationMammalian 5-LipoxygenaseCarbonyl Metabolism +7

Structure of a small‐molecule inhibitor complexed with GlmU from <i>Haemophilus influenzae</i> reveals an allosteric binding site

Igor Mochalkin, Sandra Lightle, Lakshmi Narasimhan, +4

Protein Science

Protein AssemblyDetermined Crystal StructureGlycobiologyAllosteric Binding SiteMolecular Biology +20

Identifying Promising Compounds in Drug Discovery:  Genetic Algorithms and Some New Statistical Techniques

Abhyuday Mandal, Kjell Johnson, C. F. Jeff Wu, +1

Journal of Chemical Information and Modeling

Pharmaceutical ResearchDrug TargetEngineeringHit IdentificationChemical Biology +21

Effect of Species Differences on Stromelysin-1 (MMP-3) Inhibitor Potency

Linda L. Johnson, Dirk A. Bornemeier, Jeffrey A. Janowicz, +3

Journal of Biological Chemistry

Human IsoformsMolecular BiologyPharmacotherapySpecies DifferencesDrug Resistance +16

Conversion of NSAIDS into balanced dual inhibitors of cyclooxygenase and 5-lipoxygenase

Diane H. Boschelli, David T. Connor, M. L. HOEFLE, +2

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAnti-inflammatoryBiochemistryDual InhibitorsMedicine +8

Hydroxylamine analogs of 2,6 di-t-butylphenols: Dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors

James B. Kramer, Thomas Capiris, Jagadish C. Sircar, +10

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmacological StudyBiochemistryDual InhibitorsMedicine +10