Daniel F. Ortwine

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Benjamin Lauffer, Robert Mintzer, Rina Fong et al. · Journal of Biological Chemistry · 2013 · 412 citations · Full text

Medicine, Oncology, Pharmacology +15

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

Shivani Ahuja, Susmith Mukund, Lunbin Deng et al. · Science · 2015 · 327 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development

James J. Crawford, Adam R. Johnson, Dinah Misner et al. · Journal of Medicinal Chemistry · 2018 · 247 citations · Full text

Medicine, Immunology, Pharmacology +17

Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects

Adam R. Johnson, A.G. Pavlovsky, Daniel F. Ortwine et al. · Journal of Biological Chemistry · 2007 · 211 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus

Bruce D. Roth, C. John Blankley, Alexander Chucholowski et al. · Journal of Medicinal Chemistry · 1991 · 183 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13