Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Benjamin Lauffer, Robert Mintzer, Rina Fong, +16

Journal of Biological Chemistry

Human Vascular Endothelial Cells Are a Rich and Regulatable Source of Secretory Sphingomyelinase

Sudhir Marathe, Scott L. Schissel, Michael Yellin, +4

Journal of Biological Chemistry

Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors

Steven T. Staben, Jianwen A. Feng, Karen S. Lyle, +21

Journal of Medicinal Chemistry

Compound 17Structure-based MethodsKinase InhibitorsGroup Ii PaksChemical Biology +16

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors

James J. Crawford, Wendy Lee, Ignacio Aliagas, +16

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryDrug TargetBiochemistryMedicine +10

A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase

Marian Seto, Marc Whitlow, Margaret A. McCarrick, +7

Protein Science

Aldo-keto ReductaseProtein AssemblyDimetal CoordinatingMolecular BiologyChemical Biology +14

A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C

Robert Mintzer, Sreemathy Ramaswamy, Kinjalkumar Shah, +7

PLoS ONE

Immunocytochemical TechniqueApoptosisCell DeathNeurochemical BiomarkersCytoskeleton +26

A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

J. Hiroshi Morisaki, Peter A. Smith, Shailesh V. Date, +16

mBio

Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors

Wendy Lee, James J. Crawford, Ignacio Aliagas, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +6

Differential Effects of IFN-β1b on the Proliferation of Human Vascular Smooth Muscle and Endothelial Cells

Robert Mintzer, Ed Croze, Gabor M. Rubanyi, +1

Journal of Interferon & Cytokine Research

A Novel High-Throughput Screening Format to Identify Inhibitors of Secreted Acid Sphingomyelinase

Robert Mintzer, Kenneth C. Appell, Andrew G. Cole, +6

SLAS DISCOVERY