The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang, David W. White, Bryson D. Bennett et al. · Nature · 2009 · 4K citations · Full text

Tumor Biology, Cancer-associated Idh1 Mutations, Oncogenic Agent +4

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

Mary Selak, Sean M. Armour, Elaine D. MacKenzie et al. · Cancer Cell · 2005 · 2K citations · Full text

Redox Signaling, Cellular Enzymology, Biochemistry +7

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Patrick S. Ward, Jay Patel, David R. Wise et al. · Cancer Cell · 2010 · 2K citations · Full text

Somatic Variant, Biochemistry, Medicine +10

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

Gillian L. Dalgliesh, Kyle Furge, Chris Greenman et al. · Nature · 2010 · 1.2K citations · Full text

Chromatin, Cancer Research, Urology +11

Glioma-Derived Mutations in <i>IDH1</i> Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

Shimin Zhao, Yan Lin, Wei Xu et al. · Science · 2009 · 1.1K citations