David R. Wise

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Patrick S. Ward, Jay Patel, David R. Wise et al. · Cancer Cell · 2010 · 2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

David R. Wise, Ralph J. DeBerardinis, Anthony Mancuso et al. · Proceedings of the National Academy of Sciences · 2008 · 2K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

David R. Wise, Patrick S. Ward, Jessica E.S. Shay et al. · Proceedings of the National Academy of Sciences · 2011 · 968 citations

Life Sciences, Biochemistry, Cell Biology +17

Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling

Eric G. Bluemn, Ilsa M. Coleman, Jared M. Lucas et al. · Cancer Cell · 2017 · 756 citations · Full text

Life Sciences, Molecular Biology, Oncology +14

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

Guoliang Qing, Bo Li, Annette Vu et al. · Cancer Cell · 2012 · 386 citations · Full text

Life Sciences, Cell Biology, Oncology +14