Jay Patel

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

María E. Figueroa, Omar Abdel‐Wahab, Chao Lü et al. · Cancer Cell · 2010 · 2.7K citations · Full text

Hematological Malignancy, Somatic Variant, Hypermethylation Phenotype +10

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Patrick S. Ward, Jay Patel, David R. Wise et al. · Cancer Cell · 2010 · 2K citations · Full text

Somatic Variant, Biochemistry, Medicine +10

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

Kelly Moran-Crusio, Linsey B. Reavie, Alan H. Shih et al. · Cancer Cell · 2011 · 1.3K citations · Full text

Developmental Biology, Medicine, Stem Cell Mobilization +8

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

Omar Abdel‐Wahab, Ann Mullally, Cyrus V. Hedvat et al. · Blood · 2009 · 713 citations · Full text

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

Panagiotis Ntziachristos, Aristotelis Tsirigos, Pieter Van Vlierberghe et al. · Nature Medicine · 2012 · 524 citations · Full text

Hematological Malignancy, Chromatin, Genetic Inactivation +8