Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

María E. Figueroa, Omar Abdel‐Wahab, Chao Lü, +23

Cancer Cell

Hematological MalignancySomatic VariantHypermethylation PhenotypeMedicineGenetics +8

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Patrick S. Ward, Jay Patel, David R. Wise, +13

Cancer Cell

Somatic VariantBiochemistryMedicineGeneticsInherited Metabolic Disease +8

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

Kelly Moran-Crusio, Linsey B. Reavie, Alan H. Shih, +21

Cancer Cell

Developmental BiologyMedicineStem Cell MobilizationHematologyTet2 Loss Leads +6

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

Omar Abdel‐Wahab, Ann Mullally, Cyrus V. Hedvat, +21

Blood

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

Panagiotis Ntziachristos, Aristotelis Tsirigos, Pieter Van Vlierberghe, +25

Nature Medicine

Hematological MalignancyChromatinGenetic InactivationMixed-phenotype Acute LeukemiaGenetics +6

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Sheng Li, Francine E. Garrett-Bakelman, Stephen S. Chung, +30

Nature Medicine

Hematological MalignancyChromatinDistinct EvolutionEpigenetic ChangeGenetics +8

Genetic Analysis of Transforming Events That Convert Chronic Myeloproliferative Neoplasms to Leukemias

Omar Abdel‐Wahab, Taghi Manshouri, Jay Patel, +8

Cancer Research

IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis

Ayalew Tefferi, Terra L. Lasho, Omar Abdel‐Wahab, +13

Leukemia

Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting

Jie He, Omar Abdel‐Wahab, Michelle Nahas, +48

Blood

DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

Raajit K. Rampal, Altuna Alkalin, Jozef Madžo, +31

Cell Reports