Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

Panagiotis Ntziachristos, Aristotelis Tsirigos, Pieter Van Vlierberghe, +25

Nature Medicine

Hematological MalignancyChromatinGenetic InactivationMixed-phenotype Acute LeukemiaGenetics +6

Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia

Thomas Trimarchi, Erhan Bilal, Panagiotis Ntziachristos, +4

Cell

Hematological MalignancyChromatinTranscriptional RegulationFunctional GenomicsMedicine +9

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

Bryan H. King, Thomas Trimarchi, Linsey B. Reavie, +11

Cell

Hematological MalignancyChromatinTranscriptional RegulationCell RegulationMyc Stability +6

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

Panagiotis Ntziachristos, Aristotelis Tsirigos, G. Grant Welstead, +23

Nature

Histone ModificationsChromatinTumor BiologyAcute Lymphoblastic LeukaemiaHematological Malignancy +12

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

Jinghui Zhang, Kelly McCastlain, Hiroki Yoshihara, +73

Nature Genetics

Hematological MalignancyMixed-phenotype Acute LeukemiaHematologyAcute Lymphoblastic LeukemiaMedicine +2

Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

Andreas Kloetgen, Palaniraja Thandapani, Panagiotis Ntziachristos, +17

Nature Genetics

ChromatinMixed-phenotype Acute LeukemiaNuclear OrganizationAdult T-cell Leukemia-lymphomaMedicine +3

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes

Raffaella Di Micco, Bárbara Fontanals-Cirera, Vivien Low, +14

Cell Reports

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Lu Wang, Zibo Zhao, Patrick A. Ozark, +16

Nature Medicine

Cancer TherapyChromatinChromatin RemodelingEpigenetic ChangeEpigenomics +8

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

Camille Lobry, Panagiotis Ntziachristos, Delphine Ndiaye‐Lobry, +13

The Journal of Experimental Medicine

Mixed-phenotype Acute LeukemiaImmunologyTumor BiologyMyeloid NeoplasiaHematological Malignancy +14

Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries

Yixiao Gong, Charalampos Lazaris, Theodore Sakellaropoulos, +5

Nature Communications

Strong BoundariesEngineeringGeneticsEpigeneticsTad Boundary Strength +19