Ivanhoe K. H. Leung

The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases

Rasheduzzaman Chowdhury, Kar Kheng Yeoh, Ya‐Min Tian et al. · EMBO Reports · 2011 · 1K citations · Full text

Histone Modifications, Chromatin, Biochemistry +6

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

Tzu‐Lan Yeh, T.M. Leissing, Martine I. Abboud et al. · Chemical Science · 2017 · 219 citations · Full text

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

Nathan R. Rose, Esther C. Y. Woon, Anthony Tumber et al. · Journal of Medicinal Chemistry · 2012 · 148 citations · Full text

Histone Modifications, Epigenetic Change, Chemical Biology +18

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Ya‐Min Tian et al. · Nature Communications · 2016 · 145 citations · Full text

Structural and Mechanistic Studies on γ-Butyrobetaine Hydroxylase

Ivanhoe K. H. Leung, T. Krojer, Grazyna Kochan et al. · Chemistry & Biology · 2010 · 99 citations

γ-Butyrobetaine Hydroxylase, Biochemistry, Enzyme Catalysis +2