Nathan R. Rose

The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases

Rasheduzzaman Chowdhury, Kar Kheng Yeoh, Ya‐Min Tian et al. · EMBO Reports · 2011 · 1K citations · Full text

Histone Modifications, Chromatin, Biochemistry +6

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

Anca M. Farcas, Neil P. Blackledge, Ian Sudbery et al. · eLife · 2012 · 470 citations · Full text

Biology, Chromatin, Developmental Biology +15

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Stanley S. Ng, K.L. Kavanagh, M.A. McDonough et al. · Nature · 2007 · 320 citations

Chromatin, Chromatin Structure, Biochemistry +12

Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases

Nathan R. Rose, Stanley S. Ng, Jasmin Mecinović et al. · Journal of Medicinal Chemistry · 2008 · 247 citations · Full text

Histone Modifications, Epigenetic Change, Inhibitor Scaffolds +18

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

Oliver N. F. King, Xuan Shirley Li, Masaaki Sakurai et al. · PLoS ONE · 2010 · 222 citations · Full text