Concepedia

Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease

Srinivasan Nagarajan, Gary A. De Crescenzo, Daniel P. Getman, Hwang-Fun Lu, James A. Sikorski, Jeffrey L Walker, Joseph J. McDonald, Kathryn Houseman, Geralyn P. Kocan, Nandini Kishore,

Bioorganic & Medicinal Chemistry · 2003 · 96 citations · 18 references

DOI

Concepts

References

18

Active human immunodeficiency virus protease is required for viral infectivity.

Nancy E. Kohl, Emilio A. Emini, William A. Schleif et al. · Proceedings of the National Academy of Sciences · 1988 · 1.3K citations · Full text

, , +17

Rational Design of Peptide-Based HIV Proteinase Inhibitors

Noel A. Roberts, Joseph A. Martin, Derek Kinchington et al. · Science · 1990 · 925 citations

, , +17

Viracept (Nelfinavir Mesylate, AG1343):  A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease

Stephen W. Kaldor, Vincent J. Kalish, Jay F. Davies et al. · Journal of Medicinal Chemistry · 1997 · 620 citations · Full text

, , +17

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

Dale J. Kempf, Kennan C. Marsh, Jon F. Denissen et al. · Proceedings of the National Academy of Sciences · 1995 · 556 citations

, , +16

ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

Hing L. Sham, Dale J. Kempf, Akhteruzammen Molla et al. · Antimicrobial Agents and Chemotherapy · 1998 · 470 citations · Full text

, , +16