Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

Kamran Ghoreschi, Michael I. Jesson, Li Xiong, +17

The Journal of Immunology

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

Debra M. Meyer, Michael I. Jesson, Xiong Li, +11

Journal of Inflammation

A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts

Nandini Kishore, Cindy Sommers, Sumathy Mathialagan, +12

Journal of Biological Chemistry

IKK-i and TBK-1 are Enzymatically Distinct from the Homologous Enzyme IKK-2

Nandini Kishore, Q K Huynh, Sumathy Mathialagan, +11

Journal of Biological Chemistry

JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production

Timothy P. LaBranche, Michael I. Jesson, Chad Storer, +17

Arthritis & Rheumatism

Preclinical to Clinical Translation of Tofacitinib, a Janus Kinase Inhibitor, in Rheumatoid Arthritis

Martin E. Dowty, Michael I. Jesson, Sarbani Ghosh, +4

Journal of Pharmacology and Experimental Therapeutics

Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease

Srinivasan Nagarajan, Gary A. De Crescenzo, Daniel P. Getman, +10

Bioorganic & Medicinal Chemistry

Hiv-1 ProteaseBiochemistryMedicineAntiviral Drug DevelopmentAntiviral Drug +5

A Novel, Highly Selective, Tight Binding IκB Kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear Factor-κB Pathway in Arthritis-Relevant Cells and Animal Models

Gabriel Mbalaviele, Cynthia D. Sommers, Sheri L. Bonar, +11

Journal of Pharmacology and Experimental Therapeutics

Protein Kinase Cζ Mediates Cigarette Smoke/Aldehyde- and Lipopolysaccharide-induced Lung Inflammation and Histone Modifications

Hongwei Yao, Jae‐Woong Hwang, Jorge Moscat, +5

Journal of Biological Chemistry

Histone ModificationsInflammatory Lung DiseaseLung InflammationImmunologyOxidative Stress +16

Anti-inflammatory effect of a selective IκB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke

R. Saravanan, Jae‐Woong Hwang, Hongwei Yao, +2

Pulmonary Pharmacology & Therapeutics

InflammationInflammatory Lung DiseaseLung InflammationMedicineRespiratory Toxicology +10