Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

Kamran Ghoreschi, Michael I. Jesson, Li Xiong, +17

The Journal of Immunology

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

Debra M. Meyer, Michael I. Jesson, Xiong Li, +11

Journal of Inflammation

JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production

Timothy P. LaBranche, Michael I. Jesson, Chad Storer, +17

Arthritis & Rheumatism

Preclinical to Clinical Translation of Tofacitinib, a Janus Kinase Inhibitor, in Rheumatoid Arthritis

Martin E. Dowty, Michael I. Jesson, Sarbani Ghosh, +4

Journal of Pharmacology and Experimental Therapeutics

Th17 cells can provide B cell help in autoantibody induced arthritis

Cynthia L. Hickman‐Brecks, Jennifer Racz, Debra M. Meyer, +2

Journal of Autoimmunity

InflammationRheumatologyB Cell HelpAutoantibody Induced ArthritisRheumatoid Disorder +11

Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS’ role in disease

Olga V. Nemirovskiy, Melissa R. Radabaugh, Poonam Aggarwal, +6

Nitric Oxide

InflammationRheumatologyPlasma 3-NitrotyrosineInos ’ RoleRheumatoid Disorder +11

Novel Tight-Binding Inhibitory Factor-κB Kinase (IKK-2) Inhibitors Demonstrate Target-Specific Anti-Inflammatory Activities in Cellular Assays and following Oral and Local Delivery in an in Vivo Model of Airway Inflammation

Cynthia D. Sommers, Janice Thompson, Julia A. Guzova, +14

Journal of Pharmacology and Experimental Therapeutics

Characterization of the KRN Cell Transfer Model of Rheumatoid Arthritis (KRN-CTM), a Chronic Yet Synchronized Version of the K/BxN Mouse

Timothy P. LaBranche, Cynthia L. Hickman‐Brecks, Debra M. Meyer, +9

American Journal Of Pathology

InflammationRheumatologyRheumatoid DisorderAutoimmune DiseaseCell Signaling +12

Best Practices in Bioassay Development to Support Registration of Biopharmaceuticals

John R. White, Marla Abodeely, Sammina Ahmed, +12

BioTechniques

EngineeringSupport RegistrationDrug LifecyclePre-clinical PharmacologyBioanalysis +18

A peptide isolated by phage display binds to ICAM-1 and inhibits binding to LFA-1

Joseph K. Welply, Christina N. Steininger, Maire H. Caparon, +7

Proteins Structure Function and Bioinformatics