Concepedia

A Role for Presenilin 1 in Regulating the Delivery of Amyloid Precursor Protein to the Cell Surface

Jae Yoon Leem, Carlos A. Saura, Claus U. Pietrzik, John O. Christianson, Christian Wanamaker, LaShaunda T. King, Margaret Veselits, Taisuke Tomita, Laura Gasparini, Takeshi Iwatsubo,

Neurobiology of Disease · 2002 · 72 citations · 55 references

DOIFull text

Open access

Concepts

References

55

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Robin Sherrington, Yuh‐Jin Liang, Ekaterina Rogaeva et al. · Nature · 1995 · 4K citations

, , +14

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

Ephrat Levy‐Lahad, Wilma Wasco, Parvoneh Poorkaj et al. · Science · 1995 · 2.6K citations

, , +14

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

, , +12

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

Robin Sherrington, Ekaterina Rogaeva, Georges Lévesque et al. · Nature · 1995 · 2.1K citations

, , +14

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

, , +8