Concepedia

Amyloid Nucleation

Amyloid Nucleation is a biochemical process in which soluble amyloidogenic proteins undergo a critical conformational transition to form stable oligomeric seeds that serve as templates for subsequent fibril elongation in the pathogenesis of amyloid disorders.

2K

Publications

153.2K

Citations

8K

Authors

1.8K

Institutions

Publications per year

2017–2026

580

Parents

Publications

2K

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

Joseph T. Jarrett, Elizabeth P. Berger, Peter T. Lansbury · Biochemistry · 1993 · 2K citations

, , +17

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper, Paul Säftig, Katleen Craessaerts et al. · Nature · 1998 · 1.8K citations

, , +15

Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

James Cleary, Dominic M. Walsh, J. Hofmeister et al. · Nature Neuroscience · 2004 · 1.7K citations

, , +16

Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils

Aneta T. Petkova, Richard D. Leapman, Zhihong Guo et al. · Science · 2005 · 1.7K citations

, , +17

Role of <i>Escherichia coli</i> Curli Operons in Directing Amyloid Fiber Formation

Matthew R. Chapman, Lloyd S. Robinson, Jerome S. Pinkner et al. · Science · 2002 · 1.3K citations · Full text

, , +17

1–5 of 2K

Authors

8K

  1. CM
    Christopher M. Dobson

    University of Cambridge, United Kingdom

    36 publications · 7.4K citations

    34

    h-index

  2. YG
    Yuji Goto

    The University of Osaka, Japan

    42 publications · 2.6K citations

    27

    h-index

  3. TP
    Tuomas P. J. Knowles

    University of Cambridge, United Kingdom

    28 publications · 3.5K citations

    26

    h-index

  4. HN
    Hironobu Naiki

    University of Fukui, Japan

    26 publications · 2.1K citations

    22

    h-index

  5. PW
    Per Westermark

    Uppsala University, Sweden

    23 publications · 3.3K citations

    22

    h-index

1–5 of 8K

Institutions

1.8K

  1. University of Cambridge

    Cambridge, United Kingdom

    51 h-index

    275 publications

    35.5K citations

  2. Harvard University

    Cambridge, United States

    38 h-index

    151 publications

    41K citations

  3. The University of Osaka

    Osaka, Japan

    32 h-index

    235 publications

    15.4K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    31 h-index

    185 publications

    10.9K citations

  5. National Institutes of Health

    Bethesda, United States

    28 h-index

    97 publications

    13.5K citations

  6. ETH Zurich

    Zurich, Switzerland

    28 h-index

    155 publications

    10.8K citations

  7. Linköping University

    Linköping, Sweden

    27 h-index

    72 publications

    7.4K citations

  8. University of Leeds

    Leeds, United Kingdom

    27 h-index

    113 publications

    14.9K citations

1–8 of 1.8K

Venues

  1. Journal of Molecular Biology

    JMB · 120 publications · 10.1K citations

    61

    h-index

  2. Journal of Biological Chemistry

    JBC · 107 publications · 11K citations

    57

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 72 publications · 13K citations

    53

    h-index

  4. Biochemistry

    78 publications · 9.8K citations

    46

    h-index

  5. Journal of the American Chemical Society

    JACS · 42 publications · 4.4K citations

    36

    h-index

1–5