Georges Lévesque

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Robin Sherrington, Yuh‐Jin Liang, Ekaterina Rogaeva et al. · Nature · 1995 · 4K citations

Neurodegenerative Diseases, Early-onset Familial Alzheimer, Alzheimer's Disease +7

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

Robin Sherrington, Ekaterina Rogaeva, Georges Lévesque et al. · Nature · 1995 · 2.1K citations

Disease Heterogeneity, Alzheimer's Disease, Mendelian Disorder +10

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Martin Citron, David Westaway, Weiming Xia et al. · Nature Medicine · 1997 · 1.3K citations

Neurodegenerative Diseases, Alzheimer's Disease, Molecular Neuroscience +12

The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

Gang Yu, Fusheng Chen, Georges Lévesque et al. · Journal of Biological Chemistry · 1998 · 369 citations · Full text

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex

Masaki Nishimura, Gang Yu, Georges Lévesque et al. · Nature Medicine · 1999 · 222 citations

Neurodegenerative Diseases, Alzheimer's Disease, Presenilin Mutations +9