Concepedia

Protein Aggregation Disorders

Protein Aggregation Disorders is a class of neurodegenerative diseases characterized by the abnormal accumulation of misfolded proteins in neuronal tissues, leading to cellular dysfunction and progressive neurological decline.

9.6K

Publications

850.5K

Citations

39.7K

Authors

5.2K

Institutions

Publications per year

2017–2026

3K

Variants

Protein Misfolding DiseasesProteinopathies

Parents

Children

Publications

9.6K

Lecanemab in Early Alzheimer’s Disease

Christopher H. van Dyck, Chad J. Swanson, Paul Aisen et al. · New England Journal of Medicine · 2022 · 5.2K citations · Full text

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alison Goate, Marie‐Christine Chartier‐Harlin, Jeremy Brown et al. · Nature · 1991 · 4.6K citations

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark et al. · Journal of Biological Chemistry · 2007 · 4.5K citations · Full text

, , +17

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Colin L. Masters, G. Simms, Nicola A. Weinman et al. · Proceedings of the National Academy of Sciences · 1985 · 4.4K citations · Full text

, , +17

α-Synuclein Locus Triplication Causes Parkinson's Disease

Andrew Singleton, Matthew J. Farrer, Janel Johnson et al. · Science · 2003 · 4.4K citations

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1–5 of 9.6K

Authors

39.7K

  1. JQ
    John Q. Trojanowski

    University of Pennsylvania, United States

    105 publications · 24.4K citations

    70

    h-index

  2. VM
    Virginia M.‐Y. Lee

    University of Pennsylvania, United States

    95 publications · 25.9K citations

    68

    h-index

  3. DW
    Dennis W. Dickson

    Mayo Clinic in Florida, United States

    86 publications · 12.7K citations

    57

    h-index

  4. EM
    Eliezer Masliah

    University of California San Diego, United States

    80 publications · 18.2K citations

    56

    h-index

  5. MG
    Michel Goedert

    MRC Laboratory of Molecular Biology, United Kingdom

    67 publications · 15.7K citations

    51

    h-index

1–5 of 39.7K

Institutions

5.2K

  1. Harvard University

    Cambridge, United States

    109 h-index

    903 publications

    197.7K citations

  2. University of Pennsylvania

    Philadelphia, United States

    100 h-index

    931 publications

    199.8K citations

  3. University of Cambridge

    Cambridge, United Kingdom

    88 h-index

    1K publications

    126.2K citations

  4. Mayo Clinic in Florida

    Jacksonville, United States

    84 h-index

    862 publications

    273.5K citations

  5. University College London

    London, United Kingdom

    83 h-index

    922 publications

    116.7K citations

  6. Brigham and Women's Hospital

    Boston, United States

    77 h-index

    504 publications

    127.4K citations

  7. University of California San Diego

    San Diego, United States

    75 h-index

    507 publications

    77.1K citations

  8. National Institutes of Health

    Bethesda, United States

    70 h-index

    558 publications

    168.1K citations

1–8 of 5.2K

Venues

  1. Journal of Biological Chemistry

    JBC · 463 publications · 62.5K citations

    132

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 247 publications · 54.2K citations

    130

    h-index

  3. Acta Neuropathologica

    300 publications · 30.3K citations

    96

    h-index

  4. Human Molecular Genetics

    231 publications · 29.5K citations

    96

    h-index

  5. Journal of Neuroscience

    147 publications · 27.5K citations

    94

    h-index

1–5